한빛사논문
- 조회857
Dong-Hyun Kang1,2,5, Won Bae Han1,3,5, Hyun Il Ryu1, Nam Hyuk Kim4, Tae Young Kim1, Nakwon Choi1,3, Ji Yoon Kang1, Yeon Gyu Yu4 & Tae Song Kim1,*
1Creative Research Center for Brain Science, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea. 2Micro Nano Fab Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea. 3KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. 4Department of Chemistry, Kookmin University, 77 Jeongneung-ro, Seongbuk-gu, Seoul 02707, Republic of Korea. 5These authors contributed equally: Dong-Hyun Kang, Won Bae Han.
*Corresponding author.
Abstract
Owing to their excellent durability, tunable physical properties, and biofunctionality, block copolymer-based membranes provide a platform for various biotechnological applications. However, conventional approaches for fabricating block copolymer membranes produce only planar or suspended polymersome structures, which limits their utilization. This study is the first to demonstrate that an electric-field-assisted self-assembly technique can allow controllable and scalable fabrication of 3-dimensional block copolymer artificial cell membranes (3DBCPMs) immobilized on predefined locations. Topographically and chemically structured microwell array templates facilitate uniform patterning of block copolymers and serve as reactors for the effective growth of 3DBCPMs. Modulating the concentration of the block copolymer and the amplitude/frequency of the electric field generates 3DBCPMs with diverse shapes, controlled sizes, and high stability (100% survival over 50 days). In vitro protein–membrane assays and mimicking of human intestinal organs highlight the potential of 3DBCPMs for a variety of biological applications such as artificial cells, cell-mimetic biosensors, and bioreactors.
논문정보
- Research article
- 2022년 03월 (BRIC 등록일 2022-03-25)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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