한빛사논문
- 조회515
Ye Eun Kim†, Seung Woo Choi‡, Min Kyung Kim‡, Thanh Loc Nguyen†, and Jaeyun Kim*,†,‡,§∥
†School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
‡Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University (SKKU), Seoul 06355, Republic of Korea
§Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
∥Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
*Correspondence should be addressed to Prof. J. Kim.
Ye Eun Kim and Seung Woo Choi contributed equally to this work.
Abstract
Atopic dermatitis (AD) is a chronic inflammatory disease associated with unbalanced immune responses in skin tissue. Although steroid drugs and antihistamines are generally used to treat AD, continuous administration causes multiple side effects. High oxidative stress derived from reactive oxygen species (ROS) has been implicated in the pathogenesis of AD. A high level of ROS promotes the release of pro-inflammatory cytokines and T-cell differentiation, resulting in the onset and deterioration of AD. Here, we report a therapeutic hydrogel patch suppressing the high oxidative stress generated in AD lesions. The hydrogel embedded with ROS-scavenging ceria nanoparticles leads to the decrease of both extracellular and intracellular ROS and exhibits cytoprotective effects in a highly oxidative condition. AD-induced mouse model studies show enhanced therapeutic outcomes, including a decrease in the epidermal thickness and levels of AD-associated immunological biomarkers. These findings indicate that a ROS-scavenging hydrogel could be a promising therapeutic hydrogel patch for treating and managing AD.
논문정보
- Research article
- 2022년 02월 (BRIC 등록일 2022-03-15)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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