한빛사논문
- 조회689
Shenqiang Wang1,3,4,†, Letao Yang4,6,†, Bolei Cai5,†, Fuwei Liu5, Yannan Hou4, Hua Zheng1, Fang Cheng1, Hepeng Zhang1,2,3, Le Wang5, Xiaoyi Wang5, Qianxin Lv5, Liang Kong5*, Ki-Bum Lee4* and Qiuyu Zhang1,2,3*
1 Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710129, China. 2 Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China 3 Xi’an Key Laboratory of Functional Organic Porous Materials, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China 4 Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA 5 State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China 6 Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA († These authors have contributed equally to this manuscript)
*Corresponding author.
Abstract
Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival, and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic three-dimensional (3D) cell-cell and cell-matrix interactions, creating a favourable physical microenvironment for stem cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem cell assembly method, we provide a promising approach to better overcome the inhibitory microenvironment associated with cartilage injuries and to advance current stem cell-based tissue engineering.
논문정보
- Research article
- 2022년 02월 (BRIC 등록일 2022-03-03)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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