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Adv. Sci., First published: 29 January 2022 | https://doi.org/10.1002/advs.202103254 Smart Wireless Near-Infrared Light Emitting Contact Lens for the Treatment of Diabetic Retinopathy

Geon-Hui Lee^†, Cheonhoo Jeon^†, Jee Won Mok, Sangbaie Shin, Su-Kyoung Kim, Hye Hyeon Han, Seong-Jong Kim, Sang Hoon Hong, Hwanhee Kim, Choun-Ki Joo, Jae-Yoon Sim, and Sei Kwang Hahn^*

Geon-Hui Lee, Su-Kyoung Kim, Hye Hyeon Han, Seong-Jong Kim, Sang Hoon Hong, Sei Kwang Hahn^*
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

Cheonhoo Jeon, Jae-Yoon Sim
Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

Jee Won Mok, Choun-Ki Joo
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul 06591, Korea.

Sangbaie Shin, Hwanhee Kim
PHI BIOMED Co., 168, Yeoksam-ro, Gangnam-gu, Seoul 06248, Korea.

†G.-H.L. and C.J, contributed equally to this work.

^*Corresponding author.

Abstract

Diabetic retinopathy is currently treated by highly invasive repeated therapeutic injections and surgical interventions without complete vision recovery. Here, a noninvasive smart wireless far red/near-infrared (NIR) light emitting contact lens developed successfully for the repeated treatment of diabetic retinopathy with significantly improved compliance. A far red/NIR light emitting diode (LED) is connected with an application-specific integrated circuit chip, wireless power, and communication systems on a PET film, which is embedded in a silicone elastomer contact lens by thermal crosslinking. After in vitro characterization, it is confirmed that the retinal vascular hyper-permeability induced by diabetic retinopathy in rabbits is reduced to a statistically significant level by simply repeated wearing of smart far red/NIR LED contact lens for 8 weeks with 120 µW light irradiation for 15 min thrice a week. Histological analysis exhibits the safety and feasibility of LED contact lenses for treating diabetic retinopathy. This platform technology for smart LED contact lens would be harnessed for various biomedical photonic applications.

논문정보

형식Research article
게재일2022년 01월 (BRIC 등록일 2022-03-14)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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