심재형 (고려대학교)

한빛사논문

조회598

고려대학교

Adv. Mater., First published: 24 January 2022 | https://doi.org/10.1002/adma.202108203 Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System

Seung Min Yang^†,1, Jae Hyung Shim^†,1, Hyun-U Cho^†,2, Tae-Min Jang¹, Gwan-Jin Ko¹, Jeongeun Shim², Tae Hee Kim³, Jia Zhu5, Sangun Park^3,4, Yoon Seok Kim¹, Su-Yeon Joung¹, Jong Chan Choe¹, Jeong-Woong Shin¹, Joong Hoon Lee¹, Yu Min Kang², Huanyu Cheng⁵, Youngmee Jung^3,6,7, Chul-Ho Lee^1*, Dong Pyo Jang^2* and Suk-Won Hwang^1*

¹KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ²Department of Biomedical Engineering, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. ³Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. ⁴Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea. ⁵Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA. ⁶School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea. ⁷Yonsei-KIST Convergence Research Institute, Seoul, 03722, Republic of Korea.

^†These authors contributed equally to this work.

^*Corresponding author.

Abstract

Although neurotransmitters are key substances closely related to evaluate degenerative brain diseases as well as regulate essential functions in the body, many research efforts have been focused on monitoring relatively associated physical, mechanical and electrophysiological parameters, rather than direct observation of such biochemical messengers. Here, we introduce a bioresorbable silicon-based neurochemical analyzer incorporated with two-dimensional transition metal dichalcogenides as a completely implantable brain-integrated system that can wirelessly monitor time-dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. Extensive range of examinations of molybdenum/tungsten disulfide (MoS₂/WS₂) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights underlying mechanisms of strong chemical and target-specific responses to the neurotransmitters along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non-dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon fiber electrodes illustrates capabilities for a potential use as a clinically accessible tool to associated neurodegenerative diseases.

Keywords: bioresorbable, transient, 2D materials, silicon nanomembranes, neurochemical

논문정보

형식Research article
게재일2022년 01월 (BRIC 등록일 2022-02-28)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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