한빛사논문
- 조회1,044
Hyejoong Jeonga,1, Wijin Kimb,1, Daheui Choia, Jiwoong Heoa, Uiyoung Hana, Se Yong Jungc, Hee Ho Parkd, Sung-Tae Honge, Ju Hyun Parkb,*, Jinkee Honga,*
aDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, Republic of Korea bDepartment of Biomedical Science, Kangwon National University, Chuncheon, Gangwon-do 24341, Republic of Korea cDepartment of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea dDepartment of Bioengineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea eDepartment of Tropical Medicine and Parasitology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
*Corresponding authors.
1These authors contributed equally.
Abstract
The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.
논문정보
- Research article
- 2022년 01월 (BRIC 등록일 2022-02-03)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
관련분야 논문보기
해당논문 저자보기
