한빛사논문
Jihyun Kim1,2, Jae Woo Shin1, Hyun-Jun Lee3, Ji Hyung Kim4, Sun Mi Choi5, Chang-Hoon Lee5, Hye Ryun Kang2,5, Seok Hee Park6,7, Yoe-Sik Bae6,7, Doo Hyun Chung8,9, Hye Young Kim1,2,*
1Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
2Seoul National University Medical Research Center, Institute of Allergy and Clinical Immunology, Seoul, South Korea
3Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, South Korea
4College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
5Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
6Department of Biological Sciences, Sungkyunkwan University, Suwon, South Korea
7Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University, Seoul, Korea
8Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea
9Laboratory of Immune Regulation, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea
*Correspondence : Hye Young Kim, Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea.
Abstract
Dear Editor,
Chronic obstructive pulmonary disease (COPD) is a group of irreversible lung diseases that include emphysema and chronic bronchiolitis.1 Many studies have shown that COPD is due to adaptive immune responses, particularly CD8+ and CD4+ T cells2, 3; however, the role(s) that innate immune cells such as innate lymphoid cells (ILCs) and granulocytes play in the pathogenesis of emphysema and COPD is largely unknown. Here, we show that neutrophils, and particularly type 3 innate lymphoid cells (ILC3s), play a key role in the development of COPD with the emphysema phenotype.
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