한빛사논문
- 조회1,182
Shijia Liu,1,2 Mao Ye,1 Gerald M. Pao,3 Samuel M. Song,2 Jinho Jhang,1 Haibei Jiang,2 Jong-Hyun Kim,1 Sukjae J. Kang,1 Dong-Il Kim,1 and Sung Han1,2,4,*
1Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
3Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
4Lead contact
*Correspondence
Abstract
Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the lateral parabrachial nucleus (PBL) are crucial for coordinating breathing with affective pain in mice. Individual PBLOprm1 neuronal activity synchronizes with breathing rhythm and responds to noxious stimuli. Manipulating PBLOprm1 activity directly changes breathing rate, affective pain perception, and anxiety. Furthermore, PBLOprm1 neurons constitute two distinct subpopulations in a “core-shell” configuration that divergently projects to the forebrain and hindbrain. Through non-overlapping projections to the central amygdala and pre-Bötzinger complex, these two subpopulations differentially regulate breathing, affective pain, and negative emotions. Moreover, these subsets form recurrent excitatory networks through reciprocal glutamatergic projections. Together, our data define the divergent parabrachial opioidergic circuits as a common neural substrate that coordinates breathing with various sensations and behaviors such as pain and emotional processing.
논문정보
- Research article
- 2021년 12월 (BRIC 등록일 2021-12-22)
- 국외 연구진
- 생명과학 > 신경생물학
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