한빛사논문
Woochan Choi1, Sang Eun Ryu1, YongJin Cheon1, Yeon-Ji Park1, Seoyeong Kim1, Eunhee Kim2, JaeHyung Koo3, Hongsoo Choi2, Cheil Moon1,4,*, Kyuhyung Kim1,5,*
1Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Republic of Korea
2Robotics Engineering Department, DGIST, Daegu 42988, Republic of Korea
3Department of New Biology, DGIST, Daegu 42988, Republic of Korea
4Convergence Research Advanced Centre for Olfaction, DGIST, Daegu 42988, Republic of Korea
5Lead contact
*Corresponding author
Abstract
Animals detect and discriminate countless environmental chemicals for their well-being and survival. Although a single chemical can trigger opposing behavioral responses depending on its concentration, the mechanisms underlying such a concentration-dependent switching remain poorly understood. Here, we show that C. elegans exhibits either attraction or avoidance of the bacteria-derived volatile chemical dimethyl trisulfide (DMTS) depending on its concentration. This behavioral switching is mediated by two different types of chemosensory neurons, both of which express the DMTS-sensitive seven-transmembrane G protein-coupled receptor (GPCR) SRI-14. These two sensory neurons share downstream interneurons that process and translate DMTS signals via distinct glutamate receptors to generate the appropriate behavioral outcome. Thus, our results present one mechanism by which an animal connects two distinct types of chemosensory neurons detecting a common ligand to alternate downstream circuitry, thus efficiently switching between specific behavioral programs based on ligand concentration.
Keywords : chemosensation, GPCR, behavioral switching, sri-14, C. elegans
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