한빛사논문
- 조회1,376
Jongoh Shin1,†, Jung‑Ran Noh2,†, Donghui Choe1, Namil Lee1, Yoseb Song1, Suhyung Cho1, Eun‑Jung Kang2, Min‑Jeong Go2, Seok Kyun Ha2, Dong‑Ho Chang3, Jae‑Hoon Kim2, Yong‑Hoon Kim2, Kyoung‑Shim Kim2, Haiyoung Jung4, Myung Hee Kim3, Bong‑Hyun Sung5, Seung‑Goo Lee5, Dae‑Hee Lee5, Byoung‑Chan Kim4,6,*, Chul‑Ho Lee2,* and Byung‑Kwan Cho1,*
1Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. 2Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea. 3Meta‑bolic Regulation Research Center, Korea Research Institute of Bioscience
and Biotechnology, Daejeon 34141, Republic of Korea. 4Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea. 5Synthetic Biology & Bioengineering Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea. 6Healthbiome Co., Ltd., Daejeon 34141, Republic of Korea.
†Jongoh Shin and Jung-Ran Noh contributed equally to this work.
*Correspondence
Abstract
Background
The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging.
Results
Here, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the microbial community and intestinal immunity of aged mice were comparable to those of young mice. The results of metagenomic data analysis underscore the importance of the high abundance of Akkermansia and the butyrate biosynthesis pathway in the rejuvenated mouse group. Furthermore, oral administration of Akkermansia sufficiently ameliorated the senescence-related phenotype in the intestinal systems in aged mice and extended the health span, as evidenced by the frailty index and restoration of muscle atrophy.
Conclusions
In conclusion, the changes in key microbial communities and their functions during ageing and three rejuvenation procedures, and the increase in the healthy lifespan of aged mice by oral administration of Akkermansia. Our results provide a rationale for developing therapeutic strategies to achieve healthy active ageing.
논문정보
- Research article
- 2021년 12월 (BRIC 등록일 2021-12-17)
- 국내 연구진
- 생명과학 > 생물공학
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