한빛사논문
한국과학기술연구원, 고려대학교
Young Uk Choa, Ju Young Leea, Ui-Jin Jeongb,c, Sang Hoon Parka, Se Lin Lima, Kyung Yeun Kimd,e, Je Wu Janga, Jong Ho Parkf, Hyun Woo Kima, Hyogeun Shinb, Ho Jeong Jeond,g, Young Mee Jungh,i, Il-Joo Chob,j,k,* and Ki Jun Yua,k,*
aDepartment of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
bCenter for Bio-Microsystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
cSchool of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea
dCenter for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
eDepartment of Mechanical Engineering, Seoul National University, Seoul 08826, Republic of Korea
fSchool of Business, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
gKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea
hCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
iSchool of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea
jSchool of Electrical and Electronics Engineering, Yonsei University, Seoul 03722, Republic of Korea
kYonsei-KIST Convergence Research Institute, Yonsei University, Seoul 03722, Republic of Korea
Y.U.C., J.Y.L., and U.-J.J. contributed equally to this work.
*To whom correspondence should be addressed.
Abstract
Transparent implantable devices have received significant attention in neuroscience and biomedical engineering by combining neural recording and optical modalities. Opaque, metal-based electrode arrays for electrophysiology block optical imaging and cause photoelectric artifacts, making them difficult to integrate with optogenetics. Here, a photoelectric artifact-free, highly conductive, and transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) electrode array is introduced as promising neural implants. The technology which is developed in this work provides transparent neural interfaces through low-cost, ultra-facile method compared with other transparent materials being applied to implantable tools. The device exhibits superior optical, mechanical, and electrical characteristics to other studies, thanks to a simple ethylene glycol immersing process. The device performance is highlighted by comparing its light stimulation efficiency and photoelectric artifact extent with conventional thin gold electrodes both in vitro and in vivo. This platform can assemble transparent neural interfaces much more efficiently than any other material candidates and thus has many potential applications.
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