한빛사논문
- 조회781
Da-Seul Kim1,2,†, Jun-Kyu Lee1,†, Jun Hyuk Kim1, Jaemin Lee1, Dong Seon Kim3, Sanghyun An3, Sung-Bin Park1, Tae-Hyung Kim2, Jong Seop Rim4, Soonchul Lee5, Dong Keun Han1,*
1Department of Biomedical Science, CHA University, Gyeonggi-do 13488, Republic of Korea. 2School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea. 3Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea. 4Fetal Stem Cell Research Center, CHA Advanced Research Institute, Gyeonggi-do 13488, Republic of Korea. 5Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Gyeonggi-do 13496, Republic of Korea.
*Corresponding author.
†These authors contributed equally to this work.
Abstract
Biodegradable polymers have been used with various systems for tissue engineering. Among them, poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for bone regeneration because of its great biocompatibility and biodegradability properties. However, there remain substantial cruxes that the by-products of PLGA result in an acidic environment at the implanting site, and the polymer has a weak mechanical property. In our previous study, magnesium hydroxide (MH) and bone extracellular matrix are combined with a PLGA scaffold (PME) to improve anti-inflammation and mechanical properties and osteoconductivity. In the present study, the development of a bioactive nanocomplex (NC) formed along with polydeoxyribonucleotide and bone morphogenetic protein 2 (BMP2) provides synergistic abilities in angiogenesis and bone regeneration. This PME hybrid scaffold immobilized with NC (PME/NC) achieves outstanding performance in anti-inflammation, angiogenesis, and osteogenesis. Such an advanced PME/NC scaffold suggests an integrated bone graft substitute for bone regeneration.
논문정보
- Research article
- 2021년 12월 (BRIC 등록일 2021-12-13)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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