한빛사논문
- 조회959
Haerin Janga, MS, Eun Gyul Kima, MS, Mina Kima, PhD, Soo Yeon Kima, MD, PhD, Yoon Hee Kimb, MD, PhD, Myung Hyun Sohna, MD, PhD, Kyung Won Kima, MD, PhD
aDepartment of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
bDepartment of Pediatrics, Gangnam Severance Hospital, Institute of Allergy, Yonsei University
College of Medicine, Seoul, Republic of Korea
Corresponding author: Kyung Won Kim
Abstract
Background
The pathophysiology of childhood food allergy (FA) and its natural history are poorly understood. Clarification of the underlying mechanism may aid in identifying novel biomarkers and strategies for clinical intervention in children with FA.
Objective
This study aimed to identify metabolites associated with the development and resolution of FA.
Methods
The metabolomic profiles of 20 children with FA and 20 healthy controls were assessed using liquid chromatography-mass spectrometry. Comparative analysis was performed to identify metabolites associated with FA and FA resolution. For subjects with FA, serum samples were collected at the time of diagnosis and after resolution to identify the changes in metabolite levels. The selected metabolites were then quantified in a quantification cohort to validate the results. Finally, genome-wide association analysis of the metabolite levels was performed.
Results
The study demonstrated a significantly higher level of sphingolipid metabolites and a lower level of acylcarnitine metabolites in children with FA than those in healthy controls. At diagnosis, subjects with resolving FA had a significantly high level of omega-3 metabolites and a low level of platelet-activating factors (PAF) compared to persistent FA. However, the level of omega-3 metabolites decreased in children with resolving FA but increased in children with persistent FA during the same time. The quantification data of omega-3 derived resolvins, PAF, and PAF acetylhydrolase activity further supported these results.
Conclusion
The lipid metabolite profile is closely related to childhood FA and FA resolution. This study suggests potential predictive biomarkers and provides insight into mechanisms underlying childhood FA.
논문정보
- Research article
- 2021년 11월 (BRIC 등록일 2021-12-07)
- 국내 연구진
- 의약학 > 응용의학
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