한빛사논문
- 조회665
Jeongho Kim1,6, Moonjung Hyun2,4,6, Masahiko Hibi3 & Young-Jai You2,3,5,*
1Department of Biological Sciences, Inha University, Incheon 22212, South Korea. 2Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA. 3Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan. 4Present address: Biological Resources Research Group, Bioenvironmental Science & Toxicology Division, Korea Institute of Toxicology (KIT), Gyeongsangnam-do 52834, South Korea. 5Present address: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. 6These authors contributed equally: Jeongho Kim, Moonjung Hyun.
*Corresponding author.
Abstract
All females adopt an evolutionary conserved reproduction strategy; under unfavorable conditions such as scarcity of food or mates, oocytes remain quiescent. However, the signals to maintain oocyte quiescence are largely unknown. Here, we report that in four different species – Caenorhabditis elegans, Caenorhabditis remanei, Drosophila melanogaster, and Danio rerio – octopamine and norepinephrine play an essential role in maintaining oocyte quiescence. In the absence of mates, the oocytes of Caenorhabditis mutants lacking octopamine signaling fail to remain quiescent, but continue to divide and become polyploid. Upon starvation, the egg chambers of D. melanogaster mutants lacking octopamine signaling fail to remain at the previtellogenic stage, but grow to full-grown egg chambers. Upon starvation, D. rerio lacking norepinephrine fails to maintain a quiescent primordial follicle and activates an excessive number of primordial follicles. Our study reveals an evolutionarily conserved function of the noradrenergic signal in maintaining quiescent oocytes.
논문정보
- Research article
- 2021년 11월 (BRIC 등록일 2021-11-30)
- 국내+국외 연구진
- 생명과학 > 신경생물학
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