한빛사논문
- 조회1,383
Namsun Chou, Hyogeun Shin, Kanghwan Kim, Uikyu Chae, Minsu Jang, Ui-Jin Jeong, Kyeong-Seob Hwang, Bumjun Yi, Seung Eun Lee, Jiwan Woo, Yakdol Cho, Changhyuk Lee, Bradley J. Baker, Soo-Jin Oh, Min-Ho Nam, Nakwon Choi, and Il-Joo Cho*
N. Chou, H. Shin, K. Kim, U. Chae, M. Jang, U.-J. Jeong, K.-S. Hwang, C. Lee, N. Choi, I.-J. Cho
Center for BioMicrosystems, Brain Science Institute Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
U. Chae, U.-J. Jeong
School of Electrical Engineering Korea University 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
K.-S. Hwang
School of Mechanical Engineering Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
B. Yi, B. J. Baker
Center for Functional Connectomics Brain Science Institute Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
S. E. Lee
Virus Facility, Research Animal Resource Center Brain Science Institute Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
J. Woo, Y. Cho, S.-J. Oh, M.-H. Nam
Center for Neuroscience, Brain Science Institute Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
N. Choi
KU-KIST Graduate School of Converging Science and Technology Korea University 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
N. Choi
Division of Bio-Medical Science and Technology, KIST School Korea University of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
I.-J. Cho
School of Electrical and Electronics Engineering Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
I.-J. Cho
Yonsei-KIST Convergence Research Institute Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea
*Corresponding author.
Abstract
Cell-type-specific, activity-dependent electrophysiology can allow in-depth analysis of functional connectivity inside complex neural circuits composed of various cell types. To date, optics-based fluorescence recording devices enable monitoring cell-type-specific activities. However, the monitoring is typically limited to a single brain region, and the temporal resolution is significantly low. Herein, a multimodal multi-shank fluorescence neural probe that allows cell-type-specific electrophysiology from multiple deep-brain regions at a high spatiotemporal resolution is presented. A photodiode and an electrode-array pair are monolithically integrated on each tip of a minimal-form-factor silicon device. Both fluorescence and electrical signals are successfully measured simultaneously in GCaMP6f expressing mice, and the cell type from sorted neural spikes is identified. The probe's capability of combined electro-optical recordings for cell-type-specific electrophysiology at multiple brain regions within a neural circuit is demonstrated. The new experimental paradigm to enable the precise investigation of functional connectivity inside and across complex neural circuits composed of various cell types is expected.
논문정보
- Research article
- 2021년 11월 (BRIC 등록일 2021-11-25)
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