한빛사논문
- 조회1,063
Sung Jun Min6,1, Jae Seo Lee6,1, Haram Nah1, Seung Hyeon Kim1, Ho-Jin Moon2, Rui L Reis2,3, Il Keun Kwon7,8,2,4 and Dong Nyoung Heo7,8,2,5
1Department of Dentistry, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
2Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
33B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco/Guimarães, Portugal
4Kyung Hee University Medical Science Research Institute, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
5Biofriends Inc., 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
Author notes
6These authors contributed equally to this work.
7These corresponding authors have made equal contributions to this work.
8Authors to whom any correspondence should be addressed.
Abstract
Three-dimensional (3D) printing shows potential for use as an advanced technology for forming biomimetic tissue and other complex structures. However, there are limits and restrictions on selection of conventional bioinks. Here we report the first 3D-printable platelet lysate (PLMA)-based hydrogel, which consists of platelet lysate from whole blood of humans that can simulate the 3D structure of tissues and can be formed into a crosslinked hydrogel layer-by-layer to build cell-laden hydrogel constructs through methacrylated photo-polymerization. Furthermore, it can be customized for use with various tissues by controlling the physical properties according to irradiation time and concentration. In particular, different cells can be mixed and printed, and the integrity of the 3D printed structure can maintain its shape after crosslinking. The bio-ink exhibits excellent cell diffusion and proliferation at low concentrations, which improves moldability and biocompatibility. The 3D-printable PLMA bioinks may constitute a new strategy to create customized microenvironments for the repair of various tissues in vivo using materials derived from the human body.
논문정보
- Research article
- 2021년 08월 (BRIC 등록일 2021-11-18)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오소재
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
관련분야 논문보기
