한빛사논문
- 조회805
Yuya Sato1,7, Seonghan Jang2,7, Kazutaka Takeshita3, Hideomi Itoh4, Hideaki Koike5, Kanako Tago6, Masahito Hayatsu6, Tomoyuki Hori1 & Yoshitomo Kikuchi2,4,*
1Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Center, 305-8569 Tsukuba, Japan. 2Graduate School of Agriculture, Hokkaido University, 060-8589 Sapporo, Japan. 3Faculty of Bioresource Sciences, Akita Prefectural University, 010-0195 Akita, Japan. 4Bioproduction Research Institute, AIST, Hokkaido Center, 062-8517 Sapporo, Japan. 5Bioproduction Research Institute, AIST, Tsukuba Center, 305-8566 Tsukuba, Japan. 6Institute for Agro-Environmental Sciences, National Agriculture and Food Research Organization (NARO), 305-8604 Tsukuba, Japan. 7These authors contributed equally: Yuya Sato, Seonghan Jang.
*Corresponding author.
Abstract
Insecticide resistance is one of the most serious problems in contemporary agriculture and public health. Although recent studies revealed that insect gut symbionts contribute to resistance, the symbiont-mediated detoxification process remains unclear. Here we report the in vivo detoxification process of an organophosphorus insecticide, fenitrothion, in the bean bug Riptortus pedestris. Using transcriptomics and reverse genetics, we reveal that gut symbiotic bacteria degrade this insecticide through a horizontally acquired insecticide-degrading enzyme into the non-insecticidal but bactericidal compound 3-methyl-4-nitrophenol, which is subsequently excreted by the host insect. This integrated “host-symbiont reciprocal detoxification relay” enables the simultaneous maintenance of symbiosis and efficient insecticide degradation. We also find that the symbiont-mediated detoxification process is analogous to the insect genome-encoded fenitrothion detoxification system present in other insects. Our findings highlight the capacity of symbiosis, combined with horizontal gene transfer in the environment, as a powerful strategy for an insect to instantly eliminate a toxic chemical compound, which could play a critical role in the human-pest arms race.
논문정보
- Research article
- 2021년 11월 (BRIC 등록일 2021-11-11)
- 국외 연구진
- 생명과학 > 미생물학
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