민경복 (서울대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회444

서울대학교 의과대학

Environ. Int., Volume 153, August 2021, 106489 | https://doi.org/10.1016/j.envint.2021.106489 Association between pyrethroids and prostate endpoints; stratified according to renal function

Dongui Hong^a,b, Jin-Young Min^c, Kyoung-bok Min^a,d,*

^aDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
^bIntegrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, Republic of Korea
^cVeterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of Korea
^dInstitute of Health Policy and Management, Medical Research Center, Seoul National University, Seoul, Republic of Korea

^*Corresponding author

Abstract

Background
Pyrethroids, one of the most commonly used pesticide classes, are considered to be selectively toxic toward insects rather than toward humans. However, there are accumulating data about pyrethroids toxicity in humans, especially sex organs. Thus, we investigated whether pyrethroids affected reproductive organs, especially the prostate gland.

Methods
With 1305 subjects who participated in the National Health and Nutrition Examination Survey, several measurements were performed: 3-phenoxybenzoic acid (3-PBA), a common metabolite of pyrethroids; prostate-specific antigen (PSA); and other covariates. Both logistic and linear regression analyses were performed after stratifying according to kidney function, which was evaluated based on the estimated glomerular filtration rate (eGFR).

Results
By logistic regression, the ORs (95% CIs) of the highest quantile to the reference group for higher total PSA were 2.039 (1.018 – 4.084) in the total study population and 2.219 (1.083–4.548) in the high eGFR group. The ORs (95% CIs) of the highest quantile to the reference group for a lower PSA ratio were 1.979 (1.057 – 3.707) in the total study population and 2.101 (1.086 – 4.064) in the high eGFR group. By linear regression, a marginally significant positive correlation between urinary 3-PBA and total PSA (β ± Standard Error = 0.049 ± 0.026, p = 0.0712) and a significant positive correlation between urinary 3-PBA and PSA ratio (β ± Standard Error = 0.018 ± 0.007, p = 0.0191) among the low eGFR group were observed.

Conclusion
This study showed that exposure to pyrethroids was associated with either increased levels of total PSA or alterations in the PSA ratio.

Keywords : Pyrethroids, Pesticide, Prostate, Kidney function, Pesticide exposure, Reproductive health

논문정보

형식Research article
게재일2021년 08월 (BRIC 등록일 2021-11-18)
연구진국내 연구진
분야

댓글 작성 로그인

CV 열람하기

연락처 보기