이평세 (성균관대학교, University of California at Berkeley, Brigham and Women’s Hospital, Harvard Medical School) | 한빛사논문 > 한빛사

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성균관대학교, University of California at Berkeley, Brigham and Women’s Hospital, Harvard Medical School

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Proc. Natl. Acad. Sci. USA, October 26, 2021, 118 (43):e2108876118 | https://doi.org/10.1073/pnas.2108876118 The genetic source tracking of human urinary exosomes

Qingfu Zhu^a,1, Liming Cheng^b,1, Chunyu Deng^c,1, Liu Huang^d, Jiaoyuan Li^b, Yong Wang^e, Meng Li^e, Qinsi Yang^e, Xianjun Dong^f, Jianzhong Su^a,e, Luke P. Lee^g,h,i,j,2, and Fei Liu^a,e,2

^aEye Hospital, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China; ^bDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; ^cSchool of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China; ^dDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; ^e
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China; ^f
Genomics and Bioinformatics Hub, Precision Neurology Program, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; ^gRenal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115; ^hDepartment of Bioengineering, University of California, Berkeley, CA 94720; ⁱDepartment of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720; and ^jInstitute of Quantum Biophysics, Department of Biophysics, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea

¹Q.Z., L.C., and C.D. contributed equally to this work.
²To whom correspondence may be addressed.

Abstract

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.

exosome origin, RNA sequencing, cancer diagnosis, biomarker discovery

논문정보

형식Research article
게재일2021년 10월 (BRIC 등록일 2021-11-01)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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