한빛사논문
- 조회465
Yuan Liu,1,2 Yue Huang,2,3 Dongyeop Kim,4 Zhi Ren,2,5 Min Jun Oh,2,5,6 David P. Cormode,3,7 Anderson T. Hara,8 Domenick T. Zero,8* Hyun Koo2,5,9*
1Department of Preventive & Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA19104, USA 2Biofilm Research Laboratories, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA19104, USA 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA 4Department of Preventive Dentistry, School of Dentistry, Jeonbuk National University, Deokjin-gu, Jeonju 54869, Korea 5Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA19104, USA 6Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA19104, USA 7Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA19104, USA 8Department of Cariology, Operative Dentistry and Dental Public Health, School of Dentistry, Indiana University, Indianapolis, IN46202, USA 9Center for Innovation & Precision Dentistry, School of Dental Medicine, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA19104, USA
*Corresponding author.
Abstract
Severe tooth decay has been associated with iron deficiency anemia that disproportionally burdens susceptible populations. Current modalities are insufficient in severe cases where pathogenic dental biofilms rapidly accumulate, requiring new antibiofilm approaches. Here, we show that ferumoxytol, a Food and Drug Administration-approved nanoparticle formulation for treating iron deficiency, exerts an alternative therapeutic activity via the catalytic activation of hydrogen peroxide, which targets bacterial pathogens in biofilms and suppresses tooth enamel decay in an intraoral human disease model. Data reveal the potent antimicrobial specificity of ferumoxytol iron oxide nanoparticles (FerIONP) against biofilms harboring Streptococcus mutans via preferential binding that promotes bacterial killing through in situ free-radical generation. Further analysis indicates that the targeting mechanism involves interactions of FerIONP with pathogen-specific glucan-binding proteins, which have a minimal effect on commensal streptococci. In addition, we demonstrate that FerIONP can detect pathogenic biofilms on natural teeth via a facile colorimetric reaction. Our findings provide clinical evidence and the theranostic potential of catalytic nanoparticles as a targeted anti-infective nanomedicine.
논문정보
- Research article
- 2021년 10월 (BRIC 등록일 2021-11-24)
- 국내+국외 연구진
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