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Biomaterials, Available online 22 October 2021, Volume 279, 121201 | https://doi.org/10.1016/j.biomaterials.2021.121201 Multifunctional micro/nanomotors As an emerging platform for smart healthcare applications

Hyunsik Choi¹, Jeeyoon Yi¹, Seong Hwi Cho, Sei Kwang Hahn^*

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk, 37673, South Korea

¹These authors equally contributed to this work.

^*Corresponding author.

Abstract

Self‐propelling micro‐ and nano-motors (MNMs) are emerging as a multifunctional platform for smart healthcare applications such as biosensing, bioimaging, and targeted drug delivery with high tissue penetration, stirring effect, and rapid drug transport. MNMs can be propelled and/or guided by chemical substances or external stimuli including ultrasound, magnetic field, and light. In addition, enzymatically powered MNMs and biohybrid micromotors have been developed using the biological components in the body. In this review, we describe emerging MNMs focusing on their smart propulsion systems, and diagnostic and therapeutic applications. Finally, we highlight several MNMs for in vivo applications and discuss the future perspectives of MNMs on their current limitations and possibilities toward further clinical applications.

Keywords : Nanomotor, Biosensing, Bioimaging, Targeted delivery, Smart healthcare

논문정보

형식Review Paper
게재일2021년 10월 (BRIC 등록일 2021-10-27)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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