한빛사논문
- 조회319
Seo Yeon Yoon, MD, PhD1, You Hyun Park, MPH2, Hyo Jeong Lee, MD3, Dae Ryong Kang, PhD4 and Yong Wook Kim, MD, PhD5
1Department of Physical Medicine and Rehabilitation, Korea University Guro Hospital, Seoul, Korea
2Department of Biostatistics, Yonsei University, Seoul, Korea
3Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, Gyeonggi-do, Korea
4Department of Precision Medicine & Biostatistics, Yonsei University Wonju College of Medicine, Wonju, Korea
5Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Korea
Corresponding Author: Yong Wook Kim
Abstract
Objective: Many previous studies, mostly performed in Western countries, on the effects of lifestyle factors on Parkinson’s disease, used baseline lifestyle characteristics without directly accounting for changes in covariate values over time. The objective of this study was to evaluate the association of repeatedly measured lifestyle factors with Parkinson’s disease risk in Korean population.
Methods: We conducted a nationwide population-based cohort study. Among 512,836 Koreans in the national health checkup database, we selected individuals who underwent health screening ≥ 3 times between 2002 and 2015 and followed up until December 31, 2015. Parkinson’s disease was defined using the International Classification of Diseases, Tenth Revision code G20 (with ≥ 3 times clinic visits for PD, to increase the diagnostic validity). Data on lifestyle factors such as smoking, alcohol consumption, and physical activity were collected using self-reported questionnaires. Logistic regression analysis with time-dependent covariates using generalized estimation equation models was performed to determine Parkinson’s disease development.
Results: During the 14-year follow-up, 2,655 patients developed Parkinson’s disease. Smoking showed a dose-response inverse association with Parkinson’s disease only in males (ex-smoker, Odds ratio [OR] =0.782, 95% confidence interval [CI] 0.713-0.858; current smoker, OR = 0.556, 95% CI 0.488-0.632). Alcohol consumption and regular physical activity were related to reduced Parkinson’s disease development in both sexes; however, alcohol consumption in males (≤ 3 per week, OR=0.717, 95% CI 0.658-0.780; ≥ 4 per week, OR = 0.745, 95% CI 0.644-0.861) and physical activity in females (moderate, OR=0.792, 95% CI 0.748-0.840; vigorous, OR = 0.830, 95% CI 0.756-0.911) had more consistent associations with Parkinson’s disease development compared to those of either sex. Participants with regular health screening showed a consistent relationship between lifestyle factors and Parkinson’s disease development, whereas lifestyle factors in those without regular health screening had a decreased relationship with PD, even smoking habit.
Conclusions: Analysis using repeatedly measured lifestyle factors showed an association between lifestyle factors and Parkinson’s disease development. Characteristics of lifestyle data including repeated measurements, timing, or regularity might influence results, and future studies with appropriate lifestyle factors could increase Parkinson’s disease risk prediction.
Classification of Evidence: This study provides Class II evidence that smoking, alcohol use, and physical activity are associated with reduced risk of Parkinson's disease in a Korean population
논문정보
- Research article
- 2021년 10월 (BRIC 등록일 2021-11-01)
- 국내 연구진
- 의약학 > 응용의학
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