한빛사논문
- 조회570
One-Sun Lee,1 Mohamed E. Madjet,2 and Khaled A. Mahmoud1
1Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, PO Box 34110 Doha, Qatar 2Max-Planck-Institut für Physik, komplexer Systeme, Nöthnitzer Straße 38, 01187 Dresden, Germany
Corresponding Authors One-Sun Lee, Khaled Mahmoud
Abstract
MXenes, two-dimensional metal carbides or nitrides with multifunctional surfaces, are one of the most promising antibacterial nanoscale materials. However, their putative bactericidal mechanism is elusive. To study their bactericidal mechanism, we investigated the interaction between a MXene nanosheet and a model bacterial membrane by molecular dynamics simulations and found that an adsorbed MXene on a membrane surface induced a local phase transition in a domain where the fluidity of the phospholipid in this domain at room temperature was comparable with that of the gel phase. The domain also showed a denser and thinner phospholipid membrane structure than the peripheral phospholipids. By comparing it with our previous experiments of the bactericidal activity of MXenes, we proposed the leakage of intercellular molecules at the phase boundary defects as a possible bactericidal mechanism of MXenes that leads to cell lysis. This study provides a useful model for tailoring new bactericidal nanomaterials.
논문정보
- Research article
- 2021년 10월 (BRIC 등록일 2021-10-22)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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