한빛사논문
- 조회390
Jaeho Parka,b,1, Bo-In Parkc,1, Young Ju Sona, Sun Hee Leea, Seung-Hoon Uma, Yu-Chan Kima,d, Myoung-Ryul Oka, Jeong-Yun Sunb,∗, Hyung-Seop Hana,∗, Hojeong Jeona,d,e,∗
aCenter for Biomaterials, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea bDepartment of Materials science and Engineering, Seoul National University (SNU), Seoul 08826, Republic of Korea cDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea dDivision of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea eKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea
1These authors contributed equally to this work.
∗Corresponding authors.
Abstract
Mg has received much attention as a next-generation implantable material owing to its biocompatibility, bone-like mechanical properties, and biodegradability in physiological environments. The application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body fluids. Here, we propose femtosecond (fs) laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material, which eventually reduces the corrosion rate. Analyses of the structural, physical, crystallographic, and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating layer. Depending on the fs laser conditions, the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO, resulting in a tightly bonded poly(lactic-co-glycolic acid) (PLGA) layer. The corrosion rate of the PLGA-coated, fs laser-treated Mg is considerably slow compared with the non-treated Mg; the treated Mg is also more biocompatible compared with the non-treated Mg. The fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg; further, it does not require any chemical treatment, thereby overcoming a potential obstacle for its clinical use.
논문정보
- Research article
- 2021년 07월 (BRIC 등록일 2021-10-22)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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