한빛사논문
- 조회526
Hyogeun Shina,1, Junweon Byunb,c,1, Donghyun Roha, Nakwon Choia,d,e, Hee-Sup Shinb,c,*, Il-Joo Choa,e,f,g,*
aCenter for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul Republic of Korea
bCenter for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea
cDepartment for Basic Science, IBS School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea
dKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea
eDivision of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, Republic of Korea
fSchool of Electrical and Electronics Engineering, Yonsei University, Seoul, Republic of Korea
gYonsei-KIST Convergence Research Institute, Yonsei University, Seoul, Republic of Korea
1These authors contributed equally to this work.
*Corresponding author.
Abstract
Competition is one of the most fundamental, yet complex, conflicts between social animals, and previous studies have indicated that the medial prefrontal cortex (mPFC) region of a brain is involved in social interactions. However, because we do not have a lightweight, wireless recording system that is free of interference, it is still unclear how the neural activity of the mPFC region is involved in the diverse, interacting behaviors that comprise competition. Herein, we present an interference-free, lightweight, wireless neural probe system that we applied to two mice to measure mPFC neural activities during a food competition test. In the test, we categorized 18 behavioral repertoires expressed by the mice. From the analysis of the neural signals during each repetition of the test, we found that the mPFC neural activity had the most positive correlation with goal-driven competitive behaviors, such as guarding resources and behaviors related to the extortion of resources. Remarkably, we found that the neural activity associated with guarding behavior was higher than that of extorting behavior, and this highlighted the importance of resource-guarding behavior for winning the competition, i.e., ‘winning a trophy is hard, but keeping it is harder’. Our approach in which a wireless system is used will enable in-depth studies of the brains of mice in their natural social interactions.
Keywords : Wireless neural probe system, Bluetooth, Food competition, Medial prefrontal cortex, Guarding behavior, Extorting behavior
논문정보
- Research article
- 2021년 09월 (BRIC 등록일 2021-10-18)
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