한빛사논문
- 조회496
Hyun Sun Choi, Yun Kee Jo, Gwang-Noh Ahn, Kye Il Joo, Dong-Pyo Kim, and Hyung Joon Cha*
H. S. Choi, G.-N. Ahn, Prof. K. I. Joo, Prof. D.-P. Kim, Prof. H. J. Cha
Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-ro, Nam-gu, Pohang 37673, Republic of Korea
Prof. Y. K. Jo
Department of Biomedical Convergence Science and Technology, School of Convergence , Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea
Prof. K. I. Joo
Division of Chemical Engineering and Materials Science, Ewha Womans University, 52 Ewgayeodae-gil, Seidaemun-gu, Seoul 03760, Republic of Korea
*To whom correspondence should be addressed.
H.S.C. and Y.K.J. contributed equally to this work.
Abstract
The esophagus is a tubular-shaped muscular organ where swallowed fluids and muscular contractions constitute a highly dynamic environment. The turbulent, coordinated processes that occur through the oropharyngeal conduit can often compromise targeted administration of therapeutic drugs to a lesion, significantly reducing therapeutic efficacy. Here, magnetically guidable drug vehicles capable of strongly adhering to target sites using a bioengineered mussel adhesive protein (MAP) to achieve localized delivery of therapeutic drugs against the hydrodynamic physiological conditions are proposed. A suite of highly uniform microparticles embedded with iron oxide (IO) nanoparticles (MAP@IO MPs) is microfluidically fabricated using the genipin-mediated covalent cross-linking of bioengineered MAP. The MAP@IO MPs are successfully targeted to a specific region and prolongedly retained in the tubular-structured passageway. In particular, orally administered MAP@IO MPs are effectively captured in the esophagus in vivo in a magnetically guidable manner. Moreover, doxorubicin (DOX)-loaded MAP@IO MPs exhibit a sustainable DOX release profile, effective anticancer therapeutic activity, and excellent biocompatibility. Thus, the magnetically guidable locomotion and robust underwater adhesive properties of the proteinaceous soft microbots can provide an intelligent modular approach for targeted locoregional therapeutics delivery to a specific lesion site in dynamic fluid-associated tubular organs such as the esophagus.
논문정보
- Research article
- 2021년 07월 (BRIC 등록일 2021-10-14)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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