한빛사논문
- 조회544
Won-Mook Choi1,†, Terry Cheuk-Fung Yip2,†, Young-Suk Lim1, Grace Lai-Hung Wong2, W Ray Kim3,*
1Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, The Republic of Korea
2CUHK Medical Data Analytics Centre, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
3Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA
†Joint first authors
*Corresponding author
Abstract
Despite several recent meta-analyses on the topic, the comparative risk of HCC in chronic hepatitis B (CHB) patients receiving entecavir (ETV) and tenofovir disoproxil fumarate (TDF) remains controversial. The controversy partly results from the arbitrary nature of significance levels leading to contradictory conclusions from very similar datasets. However, the use of observational data, which is prone to both within- and between-study heterogeneity of patient characteristics, also lends additional uncertainty. The asynchronous introduction of ETV and TDF in East Asia, where the majority of these studies have been conducted, further complicates analyses, as does the ensuing differences in follow-up time between ETV and TDF cohorts. Researchers conducting meta-analyses in this area must make many methodological decisions to mitigate bias but are ultimately limited to the methodologies of the included studies. It is therefore important for researchers, as well as the audience of published meta-analyses, to be aware of the quality of the observational studies and meta-analyses in terms of the patient characteristics, study design and statistical methodologies used. This review aims to help navigate the published meta-analyses on this topic and to provide researchers with recommendations for future work.
Key Words : Chronic hepatitis B, hepatocellular carcinoma, entecavir, tenofovir, meta-analysis
논문정보
- Review Paper
- 2021년 09월 (BRIC 등록일 2021-10-13)
- 국내+국외 연구진
- 의약학 > 응용의학
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