한빛사논문
- 조회321
Woochan Kim1,2,6, Yonghyun Gwon1,2,6, Yang-Kyung Kim3, Sunho Park1,2, Sung-Ju Kang3, Hyeng-Kyu Park4, Myung-Sun Kim3,* and Jangho Kim1,2,5,*
1Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea. 2Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju, Republic of Korea. 3Department of Orthopedics, Chonnam National University Hospital, Gwangju, Republic of Korea. 4Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School & Hospital, Gwangju, Republic of Korea. 5Institute of Nano-Stem Cells Therapeutics, NANOBIOSYSTEM Co., Ltd, Gwangju 61008, Republic of Korea. 6These authors contributed equally: Woochan Kim, Yonghyun Gwon.
*Corresponding author.
Abstract
The design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with plasma modification. Using our method, we fabricated biodegradable biomaterial (i.e., polycaprolactone (PCL))-based nitrogen gas (N-FN) and oxygen gas plasma-assisted flexible multiscale nanotopographic (O-FMN) patches with natural extracellular matrix-like hierarchical structures along with flexible and controlled hydrophilic properties. In response to multiscale nanotopographic and chemically modified surface cues, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models. Overall, the PCL-based O-FMN patches could accelerate soft- and hard-tissue regeneration. Thus, our proposed methodology was confirmed as an efficient approach for the design and manipulation of scaffolds having a multiscale topography with controlled hydrophilic property.
논문정보
- Research article
- 2021년 09월 (BRIC 등록일 2021-09-16)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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