한빛사논문
- 조회1,140
Cheol-Hwi Kim, Yoojoong Han, Yoon Choi, Minkyeong Kwon, Hyungbin Son, Zhengtang Luo, and Tae-Hyung Kim*
C.-H. Kim, Y. Choi, M. Kwon, H. Son, T.-H. Kim
School of Integrative Engineering
Chung-Ang University
Seoul 06974, Republic of Korea
Y. Han
R&D division
Nanobase, Inc.
Seoul 08502, Republic of Korea
Z. Luo
Department of Chemical and Biological Engineering
Hong Kong University of Science and Technology
Kowloon, Hong Kong 999077, P. R. China
T.-H. Kim
Integrative Research Center for Two-Dimensional Functional Materials
Institute of Interdisciplinary Convergence Research
Chung-Ang University
Seoul 06974, Republic of Korea
*Corresponding author.
Abstract
Graphene oxide (GO) has proven to be a highly promising material across various biomedical research avenues, including cancer therapy and stem cell-based regenerative medicine. However, creating a uniform GO coating as a thin layer on desired substrates has been considered challenging owing to the intrinsic variability of the size and shape of GO. Herein, a new method is introduced that enables highly uniform GO thin film (UGTF) fabrication on various biocompatible substrates. By optimizing the composition of the GO suspension and preheating process to the substrates, the “coffee-ring effect” is significantly suppressed. After applying a special postsmoothing process referred to as the low-oxygen concentration and low electrical energy plasma (LOLP) treatment, GO is converted to small fragments with a film thickness of up to several nanometers (≈5.1 nm) and a height variation of only 0.6 nm, based on atomic force microscopy images. The uniform GO thin film can also be generated as periodic micropatterns on glass and polymer substrates, which are effective in one-step micropatterning of both antibodies and mouse melanoma cells (B16-F10). Therefore, it can be concluded that the developed UGTF is useful for various graphene-based biological applications.
논문정보
- Research article
- 2021년 09월 (BRIC 등록일 2021-09-14)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
