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J. Magnes. Alloy., Available online 4 September 2021 | https://doi.org/10.1016/j.jma.2021.07.019 A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents

Kwang-Hee Cheon^a, Cheonil Park^a, Min-Ho Kang^a, Suhyung Park^a, Jinyoung Kim^a, Seol-Ha Jeong^a, Hyoun-Ee Kim^a, Hyun-Do Jung^b,c,∗, Tae-Sik Jang^d,∗

^a Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea ^b Department of Biomedical-Chemical Engineering, Catholic University of Korea, Bucheon-si, Gyeonggi-do, Republic of Korea ^c Department of Biotechnology, The Catholic University of Korea, Bucheon-si 14662, Republic of Korea ^d Department of Materials Science and Engineering, Chosun University, Gwangju, Republic of Korea

^*Corresponding author.

Abstract

Biodegradable stents made of magnesium (Mg) and its alloys have been developed to minimize persistent inflammation or in-stent restenosis, which are the main problems for permanent stents. However, their rapid corrosion behavior under physiological conditions leads to poor vascular compatibility and premature structural failure, which remains an important unsolved clinical problem. Herein, we demonstrate a new strategy for solving this problem by combining poly (ether imide) (PEI) coating and subsequent tantalum (Ta) ion implantation. The PEI coating covers the whole surface of the Mg stent uniformly via a spray coating technique and provides Mg with superior corrosion resistance and stable sirolimus-carrying ability. Ta ion implantation is conducted by a sputtering-based plasma immersion ion implantation technique only onto the luminal surface of the PEI-coated Mg stent. Its extremely short processing time (< 30 s) permits preservation of the PEI coating's corrosion protection ability and sirolimus loading characteristics. In addition, a Ta-implanted skin layer that forms on the topmost surface of the PEI coating plays an effective role in not only preventing a rapid release of sirolimus from the surface but also improving the PEI coating's surface hydrophilicity. Based on in vitro cellular response and blood compatibility tests, Ta ion implantation leads to the improvement of endothelial cell adhesion/proliferation and suppression of platelet adhesion/activation regardless of sirolimus loading. These results indicate that the combination of PEI coating and Ta ion implantation has significant innovative potential to provide excellent vascular compatibility and prevent in-stent restenosis and thrombosis.

논문정보

형식Research article
게재일2021년 09월 (BRIC 등록일 2021-09-08)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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