한빛사논문
- 조회987
Seokyoung Bang, Dongha Tahk, Young Hwan Choi, Somin Lee, Jungeun Lim, Seung-Ryeol Lee, Byung-Soo Kim, Hong Nam Kim,* Nathaniel S. Hwang,* and Noo Li Jeon*
S. Bang, H. N. Kim
Brain Science Institute
Korea Institute of Science and Technology (KIST)
Seoul 02792, Republic of Korea
D. Tahk, J. Lim, S.-R. Lee, N. L. Jeon
Department of Mechanical Engineering
Seoul National University
Seoul 08826, Republic of Korea
D. Tahk
Hennilt, Busan 46985, Republic of Korea
Y. H. Choi, B.-S. Kim, N. S. Hwang
School of Chemical and Biological Engineering
Institute of Chemical Processes and Interdisciplinary Program in Bioengineering
BioMAX Institute
Institute of Bio Engineering
Institute of Engineering Research
Seoul National University
Seoul 08826, Republic of Korea
S. Lee, N. L. Jeon
Interdisciplinary Program in Bioengineering
Seoul National University
Seoul 08826, Republic of Korea
H. N. Kim
Division of Bio-Medical Science & Technology
KIST School
Korea University of Science and Technology
Seoul 02792, Republic of Korea
N. L. Jeon
World Class University Program on Multiscale Mechanical Design
Seoul National University
Seoul 08826, Republic of Korea
N. L. Jeon
Institute of Advanced Machines and Design
Seoul National University
Seoul 08826, Republic of Korea
S.B., D.T., and Y.H.C contributed equally to this work.
*Corresponding author.
Abstract
Microphysiological systems (MPSs), based on microfabrication technologies and cell culture, can faithfully recapitulate the complex physiology of various tissues. However, 3D tissues formed using MPS have limitations in size and accessibility; their use in regenerative medicine is, therefore, still challenging. Here, an MPS-inspired scale-up vascularized engineered tissue construct that can be used in regenerative medicine is designed. Endothelial cell-laden hydrogels are sandwiched between two through-hole membranes. The microhole array in the through-hole membranes enables the molecular transport across the hydrogel layer, allowing long-term cell culture. Furthermore, the time-controlled delamination of through-hole membranes enables the harvesting of cell-cultured hydrogel constructs without damaging the capillary network. Importantly, when the tissue constructs are implanted in a mouse ischemic model, they protect against necrosis and promoted functional recovery to a greater extent than implanted cells, hydrogels, and simple gel–cell mixtures.
논문정보
- Research article
- 2021년 08월 (BRIC 등록일 2021-09-01)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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