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서울대학교

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Nat. Rev. Mol. Cell Biol., 21, 542–556 (2020). https://doi.org/10.1038/s41580-020-0246-8 A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

Sha Yu ¹, V Narry Kim ^1,2,*

¹Center for RNA Research, Institute for Basic Science, Seoul, Korea.
²School of Biological Sciences, Seoul National University, Seoul, Korea.
^*Corresponding author

Abstract

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification. The addition of tails and their composition reflect RNA maturation stages and have important roles in determining the fate of the modified RNAs. Apart from canonical poly(A) polymerases, which add poly(A) tails to mRNAs in a transcription-coupled manner, a family of terminal nucleotidyltransferases (TENTs), including terminal uridylyltransferases (TUTs), modify RNAs post-transcriptionally to control RNA stability and activity. The human genome encodes 11 different TENTs with distinct substrate specificity, intracellular localization and tissue distribution. In this Review, we discuss recent advances in our understanding of non-canonical RNA tails, with a focus on the functions of human TENTs, which include uridylation, mixed tailing and post-transcriptional polyadenylation of mRNAs, microRNAs and other types of non-coding RNA.

논문정보

형식Review Paper
게재일2020년 09월 (BRIC 등록일 2021-08-11)
연구진국내 연구진
분야 생명과학 > 세포생물학

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