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New York University

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Plant Cell, Volume 33, Issue 4, April 2021, Pages 1118–1134, | https://doi.org/10.1093/plcell/koab022 Natural variation in plant telomere length is associated with flowering time

Jae Young Choi,^1,*,† Liliia R. Abdulkina,² Jun Yin,³ Inna B. Chastukhina,² John T. Lovell,^3,4 Inna A. Agabekian,² Pierce G. Young,⁵ Samsad Razzaque,³ Dorothy E. Shippen,⁵ Thomas E. Juenger,³ Eugene V. Shakirov,^2,6,7,*,† and Michael D. Purugganan,^1,*,†

¹Department of Biology, Center for Genomics and Systems Biology, New York University, New York 10003, NY, USA ²Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Republic of Tatarstan 420008, Russia ³Department of Integrative Biology, University of Texas at Austin, Texas 78712, USA ⁴Genome Sequencing Center, HudsonAlpha Institute for Biotechnology, Alabama 35806, USA ⁵Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128, USA ⁶Department of Biological Sciences, College of Science, Marshall University, West Virginia 25701, USA ⁷Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, West Virginia 25755, USA

^*Author for correspondence

^†Senior authors.

Abstract

Telomeres are highly repetitive DNA sequences found at the ends of chromosomes that protect the chromosomes from deterioration duringcell division. Here, using whole-genome re-sequencing and terminal restriction fragment assays, we found substantial natural intraspecific variation in telomere length in Arabidopsis thaliana, rice (Oryza sativa), and maize (Zea mays). Genome-wide association study (GWAS) mapping in A. thaliana identified 13 regions with GWAS-significant associations underlying telomere length variation, including a region that harbors the telomerase reverse transcriptase (TERT) gene. Population genomic analysis provided evidence for a selective sweep at the TERT region associated with longer telomeres. We found that telomere length is negatively correlated with flowering time variation not only in A. thaliana, but also in maize and rice, indicating a link between life-history traits and chromosome integrity. Our results point to several possible reasons for this correlation, including the possibility that longer telomeres may be more adaptive in plants that have faster developmental rates (and therefore flower earlier). Our work suggests that chromosomal structure itself might be an adaptive trait associated with plant life-history strategies.

논문정보

형식Research article
게재일2021년 04월 (BRIC 등록일 2021-08-11)
연구진국외 연구진
분야 생명과학 > 유전학

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