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최유미Youmi Choe

고려대학교

Chem. Soc. Rev., First published 24 Dec 2020 | https://doi.org/10.1039/D0CS01175D Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine

Chuang Liu,^†d Jinwoo Shin,^†cSubin Son,^†c Youmi Choe,^†c Nika Farokhzad,^e Zhongmin Tang,^d Yufen Xiao,^d Na Kong,^*d Tian Xie,^*ab Jong Seung Kim^*c and Wei Tao^*d

^aCollege of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
^bKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China
^cDepartment of Chemistry, Korea University, Seoul, 02841, Korea.
^dCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
^eMilton Academy, Milton, MA 02186, USA

^†These authors contributed equally.
^*Corresponding authors

Abstract

Pnictogens (the non-metal phosphorus, metalloids arsenic and antimony, and metal bismuth) possess diverse chemical characteristics that support the formation of extended molecular structures. As witnessed by the centuries-old (and ongoing) clinical utilities, pnictogen-based compounds have secured their places in history as “magic bullet” therapeutic drugs in medicinal contexts. Moreover, with the development of recent metalloproteomics and bio-coordination chemistry, the pnictogen-based drugs functionally binding to proteins/enzymes in biological systems have been underlaid for “drug repurposing” with promising opportunities. Furthermore, advances in the modern materials science and nonotechnology have stimulated a revolution in other newly discovered forms of pnictogens—phosphorene, arsenene, antimonene, and bismuthine (layered pnictogens). Based on their favorable optoelectronic properties, layered pnictogens have shown dramatic superiority as emerging photonic nanomedicines for the treatment of various diseases. This tutorial review outlines the history and mechanism of action of ancient pnictogen-based drugs (e.g., arsenical compounds in traditional Chinese medicine) and their repurposing into modern therapeutics. Then, the revolutionary use of emerging layered pnictogens as photonic nanomedicines, alongside assessments of their in vivo biosafety, is discussed. Finally, the challenges to further development of pnictogens are set forth and insights for further exploration of their appealing properties are offered. This tutorial review may also provide some deep insights into the fields of integrated traditional Chinese and Western medicines from the perspective of materials science and nanotechnology.

논문정보

형식Review Paper
게재일2020년 12월 (BRIC 등록일 2021-08-10)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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