김자경 (연세대학교 의과대학, 용인세브란스병원) | 한빛사논문 > 한빛사

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연세대학교 의과대학, 용인세브란스병원

Cell Reports, Volume 36, Issue 4, 27 July 2021, 109438 | https://doi.org/10.1016/j.celrep.2021.109438 IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation

In-Ho Seo^1,5, Hyuk Soo Eun^2,5, Ja Kyung Kim^3,5, Hoyoung Lee¹, Seongju Jeong¹, Seong Jin Choi¹, Jeewon Lee¹, Byung Seok Lee², Seok Hyun Kim², Woo Sun Rou², Dong Hyeon Lee⁴, Won Kim^4,*, Su-Hyung Park^1,*, Eui-Cheol Shin^1,5,6,*

¹Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea
²Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea
³Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea
⁴Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Republic of Korea
⁵These authors contributed equally
⁶Lead contact

*Corresponding author

Abstract

During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. IL-15 upregulates CCR5 in memory CD8+ T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8+ T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8+ T cells.

Keywords : IL-15, bystander-activated CD8+ T cells, CCR5, migration

논문정보

형식Research article
게재일2021년 07월 (BRIC 등록일 2021-08-03)
연구진국내 연구진
분야 의약학 > 면역의학

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