한빛사논문
- 조회675
Mi-Ok Lee1,2,4, Su-gi Lee1,2,4, Cho-Rok Jung1,2,4, Ye Seul Son1,2,4, Jae-Woon Ryu1, Kwang Bo Jung1,2, Jun-Ho Ahn3, Jung-Hwa Oh3, Hyang-Ae Lee3, Jung Hwa Lim1, Janghwan Kim1,2, Insu Jang1, Jinhyuk Choi1, Jaeeun Jung1, Kunhyang Park1, Byungwook Lee1, Dae-Soo Kim1,2,5,*, Mi-Young Son1,2,5,* & Hyun-Soo Cho1,2,5,*
1Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea. 2Korea University of Science and Technology, Daejeon, Republic of Korea. 3Korea Institute of Toxicology (KIT), Daejeon, Republic of Korea. 4These authors contributed equally: Mi-Ok Lee, Su-gi Lee, Cho-Rok Jung, Ye Seul Son. 5These authors jointly supervised this work: Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho.
*Corresponding author.
Abstract
Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models in drug development and regenerative medicine. For a simple and reproducible analysis of the quality of organoids and cells to compensate for the shortcomings of existing experimental validation studies, a quantitative evaluation method should be developed. Here, using the GTEx database, we construct a quantitative calculation system to assess similarity to the human organs. To evaluate our system, we generate hPSC-derived organoids and cells, and detected organ similarity. To facilitate the access of our system by researchers, we develop a web-based user interface presenting similarity to the appropriate organs as percentages. Thus, this program could provide valuable information for the generation of high-quality organoids and cells and a strategy to guide proper lineage-oriented differentiation.
논문정보
- Research article
- 2021년 07월 (BRIC 등록일 2021-07-30)
- 국내 연구진
- 생명과학 > 노화/암생물학
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