한빛사논문
Jisun Lim1,2,†, Jinbeom Heo1,2,†, Hwan Yeul Yu1,3, HongDuck Yun1,2, Seungun Lee1,2, Hyein Ju1,3, Yun Ji Nam1,2, Seon Min Jeong1,2, Jinwon Lee1,2, You Sook Cho4, Myung-Soo Choo3, Eui Man Jeong5,6, Chae-Min Ryu1,3,*, Dong-Myung Shin1,2,*
1Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Physiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
4Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
5Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, Jeju, Korea
6Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Bio-Health Materials Core-Facility Center and Practical Translational Research Center, Jeju National University, Jeju, Korea
Correspondence : Dong-Myung Shin, PhD and Chae-Min Ryu, PhD,
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.
†Both the authors contributed equally to this work.
Abstract
Dear Editor,
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell (SC) transplantation with standard first-line treatment consisting of administration of systemic high-dose steroids. Unfortunately, effective therapies and standards of care are lacking for second-line treatment in patients with steroid-refractory disease, resulting in poor prognosis.1 Mesenchymal-SCs (MSCs) have regenerative, immunomodulatory, and anti-inflammatory properties, making their administration a promising strategy to treat incurable GVHD. MSCs, however, are heterogeneous, with differences in their morphologic and molecular characteristics, leading to different outcomes in preclinical and clinical studies.
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