채의규 (한국과학기술연구원, 고려대학교)

한빛사논문

조회921

한국과학기술연구원, 고려대학교

CV File 328 kb

Biosens. Bioelectron., Volume 191, 113473 | https://doi.org/10.1016/j.bios.2021.113473 Bimodal neural probe for highly co-localized chemical and electrical monitoring of neural activities in vivo

Uikyu Chae^a,b, Hyogeun Shin^a, Nakwon Choi^a,c, Mi-Jung Ji^d, Hyun-Mee Park^d, Soo Hyun Lee^e, Jiwan Woo^f, Yakdol Cho^f, Kanghwan Kim^a, Seulkee Yang^g, Min-Ho Nam^g, Hyun-Yong Yu^b, Il-Joo Cho^a,h,i,*

^aCenter for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
^bSchool of Electrical Engineering, Korea University, Seoul, Republic of Korea
^cDivision of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Daejeon, Republic of Korea
^dAdvanced Analysis Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
^eDepartment of Medical Records and Health Information Management College of Nursing and Health, Kongju National University, Gongju-si, Chungcheongnam-do, Republic of Korea
^fResearch Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
^gConvergence Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
^hSchool of Electrical and Electronics Engineering, Yonsei University, Seoul, Republic of Korea
iYonsei-KIST Convergence Research Institute, Yonsei University, Seoul, Republic of Korea

^*Corresponding author.

Abstract

Investigation of the chemical and electrical signals of cells in vivo is critical for studying functional connectivity and brain diseases. Most previous studies have observed either the electrical signals or the chemical signals of cells because recording electrical signals and neurochemicals are done by fundamentally different methods. Herein, we present a bimodal MEMS neural probe that is monolithically integrated with an array of microelectrodes for recording electrical activity, microfluidic channels for sampling extracellular fluid, and a microfluidic interface chip for multiple drug delivery and sample isolation from the localized region at the cellular level. In this work, we successfully demonstrated the functionality of our probe by monitoring and modulating bimodal (electrical and chemical) neural activities through the delivery of chemicals in a co-localized brain region in vivo. We expect our bimodal probe to provide opportunities for a variety of in-depth studies of brain functions as well as for the investigation of neural circuits related to brain diseases.

Keywords : Neural probe, Neurotransmitter, Sampling probe, Bimodal neural activity, Neuromodulation

논문정보

형식Research article
게재일2021년 06월 (BRIC 등록일 2021-07-23)
연구진국내 연구진
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