한빛사논문
- 조회681
Sohyoung Lee1,2, Sean Inzerillo1,2, Gi Young Lee1, Erick M. Bosire1, Saroj K. Mahato1, Jeongmin Song1,*
1Department of Microbiology & Immunology, Cornell University, Ithaca, New York 14853, NY, USA
2These authors contributed equally to this work.
*Corresponding author.
Abstract
Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host–pathogen interactions can benefit the pathogen, host, or both. Here, we discuss (i) bacterial glycans that play a critical role in bacterial colonization and/or immune evasion, (ii) host glycans that are utilized by bacteria for pathogenesis, and (iii) bacterial and host glycans involved in immune responses against pathogens. We further discuss (iv) opportunities and challenges for transforming these research findings into more effective antibacterial strategies, and (v) technological advances in glycoscience that have helped to accelerate progress in research. These studies collectively offer valuable insights into new perspectives on antibacterial strategies that may effectively tackle the drug-resistant pathogens that are rapidly spreading globally.
논문정보
- Review Paper
- 2021년 07월 (BRIC 등록일 2021-07-21)
- 국외 연구진
- 생명과학 > 미생물학
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