한빛사논문
- 조회876
Jae Hyung Jung1,6, Min-Seok Rha1,2,6, Moa Sa1,3, Hee Kyoung Choi4, Ji Hoon Jeon4, Hyeri Seok4, Dae Won Park4, Su-Hyung Park1,3, Hye Won Jeong5,*, Won Suk Choi4,* & Eui-Cheol Shin1,3,*
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. 2Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea. 3The Center for Epidemic Preparedness, KAIST, Daejeon, Republic of Korea. 4Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Ansan Hospital, Ansan, Republic of Korea. 5Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea. 6These authors contributed equally: Jae Hyung Jung, Min-Seok Rha.
*Corresponding author.
Abstract
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex vivo assays to evaluate SARS-CoV-2-specific CD4+ and CD8+ T cell responses in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO), and find that memory T cell responses are maintained during the study period regardless of the severity of COVID-19. In particular, we observe sustained polyfunctionality and proliferation capacity of SARS-CoV-2-specific T cells. Among SARS-CoV-2-specific CD4+ and CD8+ T cells detected by activation-induced markers, the proportion of stem cell-like memory T (TSCM) cells is increased, peaking at approximately 120 DPSO. Development of TSCM cells is confirmed by SARS-CoV-2-specific MHC-I multimer staining. Considering the self-renewal capacity and multipotency of TSCM cells, our data suggest that SARS-CoV-2-specific T cells are long-lasting after recovery from COVID-19, thus support the feasibility of effective vaccination programs as a measure for COVID-19 control.
논문정보
- Research article
- 2021년 06월 (BRIC 등록일 2021-07-06)
- 국내 연구진
- 의약학 > 면역의학
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