김승국 (Stanford University School of Medicine) | 한빛사논문 > 한빛사

한빛사논문

조회633

Stanford University School of Medicine

Cell Metab., Available online 16 June 2021 | https://doi.org/10.1016/j.cmet.2021.05.018 Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila

Seung K. Kim^1,2,3,7,*, Deborah D. Tsao¹, Greg S.B. Suh^4,*, Irene Miguel-Aliaga^5,6,*

¹Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
²Department of Medicine (Endocrinology), Stanford University School of Medicine, Stanford, CA 94305, USA
³Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA 94305, USA
⁴Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea
⁵MRC London Institute of Medical Sciences, London, UK
⁶Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK
⁷Lead contact

^*Corresponding author

Abstract

There has been rapid growth in the use of Drosophila and other invertebrate systems to dissect mechanisms governing metabolism. New assays and approaches to physiology have aligned with superlative genetic tools in fruit flies to provide a powerful platform for posing new questions, or dissecting classical problems in metabolism and disease genetics. In multiple examples, these discoveries exploit experimental advantages as-yet unavailable in mammalian systems. Here, we illustrate how fly studies have addressed long-standing questions in three broad areas—inter-organ signaling through hormonal or neural mechanisms governing metabolism, intestinal interoception and feeding, and the cellular and signaling basis of sexually dimorphic metabolism and physiology—and how these findings relate to human (patho)physiology. The imaginative application of integrative physiology and related approaches in flies to questions in metabolism is expanding, and will be an engine of discovery, revealing paradigmatic features of metabolism underlying human diseases and physiological equipoise in health.

Keywords : Drosophila melanogaster, endocrinology, hormones, sexual dimorphism, gastrointestinal tract, genetics, disease, diabetes, physiology, neuron, intestine

논문정보

형식Review Paper
게재일2021년 06월 (BRIC 등록일 2021-06-29)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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