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전원용Won-Yong Jeon

단국대학교

Biomaterials, Available online 9 June 2021, 120948 | https://doi.org/10.1016/j.biomaterials.2021.120948 Electricity auto-generating skin patch promotes wound healing process by activation of mechanosensitive ion channels

Tae-Hyun Kim^a,1, Won-Yong Jeon^a,b,1, Yunseong Ji^a,1, Eun Ju Park^a,d, Dong Suk Yoon^a, Na-Hyun Lee^a,c,f, Sung-Min Park^a,c, Nandin Mandakhbayar^a,c, Jung-Hwan Lee^{a,c,e,f,g,h,i,*}, Hae-Hyoung Lee^a,c,e,i, Hae-Won Kim^{a,c,e,f,g,h,i,*}

^aInstitute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
^bDepartment of Chemistry, Dankook University, Cheonan 31116, Republic of Korea
^cDepartment of Nanobiomedical Science and BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea
^dInstitute of Materials Research and Engineering (IMRE), A*STAR, 2 Fusionopolis Way, #08-03 Innovis, 138634, Singapore
^eDepartment of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
^fDepartment of Regenerative Dental Medicine, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
^gCell & Matter Institute, Dankook University, Cheonan 31116, Republic of Korea
^hMechanobiology Dental Medicine Research Center (MD-MRC), Cheonan 31116, Republic of Korea
ⁱUCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea

¹These authors contributed equally to this work.

^*Corresponding author.

Abstract

Electricity constitutes a natural biophysical component that preserves tissue homeostasis and modulates many biological processes, including the repair of damaged tissues. Wound healing involves intricate cellular events, such as inflammation, angiogenesis, matrix synthesis, and epithelialization whereby multiple cell types sense the environmental cues to rebuild the structure and functions. Here, we report that electricity auto-generating glucose-responsive enzymatic-biofuel-cell (EBC) skin patch stimulates the wound healing process. Rat wounded-skin model and in vitro cell cultures showed that EBC accelerated wound healing by modulating inflammation while stimulating angiogenesis, fibroblast fuctionality and matrix synthesis. Of note, EBC-activated cellular bahaviors were linked to the signalings involved with calcium influx, which predominantly dependent on the mechanosensitive ion channels, primarily Piezo1. Inhibition of Piezo1-receptor impaired the EBC-induced key functions of both fibroblasts and endothelial cells in the wound healing. This study highlights the significant roles of electricity played in wound healing through activated mechanosensitive ion channels and the calcium influx, and suggests the possibility of the electricity auto-generating EBC-based skin patch for use as a wound healing device.

Keywords : Wound healing, Electricity generation, Enzymatic biofuel cell, Ion channel, Piezo1

논문정보

형식Research article
게재일2021년 06월 (BRIC 등록일 2021-06-24)
연구진국내(교신)+국외 연구진
분야 의약학 > 재생의학

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