한빛사논문
- 조회1,123
Sung‑Hyun Kim†, Key‑Hwan Lim†, Sumin Yang and Jae‑Yeol Joo*
Neurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea
*Correspondence: Jae‑Yeol Joo
†Sung-Hyun Kim and Key-Hwan Lim have contributed equally to this work.
Abstract
Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate treatment of brain tumors. Long non-coding RNAs (lncRNAs), a type of non-coding RNA longer than 200 nucleotides, regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels and are involved in a variety of biological functions. Recent studies on lncRNAs have revealed their aberrant expression in various cancers, with distinct expression patterns associated with their instrumental roles in cancer. Abnormal expression of lncRNAs has also been identified in brain tumors. Here, we review the potential roles of lncRNAs and their biological functions in the context of brain tumors. We also summarize the current understanding of the molecular mechanisms and signaling pathways related to lncRNAs that may guide clinical trials for brain tumor therapy.
논문정보
- Review Paper
- 2021년 05월 (BRIC 등록일 2021-05-14)
- 국내 연구진
- 생명과학 > 신경생물학
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