한빛사논문, 상위피인용논문
- 조회1,022
Jinhee Hur,1 Ebunoluwa Otegbeye,2,3 Hee-Kyung Joh,1,4 Katharina Nimptsch,1,5 Kimmie Ng,6 Shuji Ogino,7,8,9 Jeffrey A Meyerhardt,6 Andrew T Chan,9,10,11,12,13 Walter C Willett,1,8,12 Kana Wu,1,* Edward Giovannucci,1,8,12,* Yin Cao3,14,15,*
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
3Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA
4Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea
5Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
6Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
7Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
8Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
9Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
10Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
11Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
12Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
13Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA
14Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
15Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA
*Contributed equally as senior authors.
Correspondence to Dr. Yin Cao
Abstract
Objective
Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined.
Design
In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported adulthood beverage intake using validated food frequency questionnaires (FFQs) every 4 years. A subset of 41 272 participants reported beverage intake at age 13–18 years using a validated high school-FFQ in 1998. Cox proportional hazards models were used to estimate relative risks (RRs) with 95% CIs.
Results
We documented 109 EO-CRC cases. Compared with individuals who consumed <1 serving/week of SSBs in adulthood, women who consumed ≥2 servings/day had a more than doubled risk of EO-CRC (RR 2.18; 95% CI 1.10 to 4.35; ptrend=0.02), with a 16% higher risk (RR 1.16; 95% CI 1.00 to 1.36) per serving/day increase. Each serving/day increment of SSB intake at age 13–18 years was associated with a 32% higher risk of EO-CRC (RR 1.32; 95% CI 1.00 to 1.75). Replacing each serving/day of adulthood SSB intake with that of artificially sweetened beverages, coffee, reduced fat milk or total milk was associated with a 17%–36% lower risk of EO-CRC.
Conclusion
Higher SSB intake in adulthood and adolescence was associated with a higher risk of EO-CRC among women. Reduction of SSB consumption among adolescents and young adults may serve as a potential strategy to alleviate the growing burden of EO-CRC.
논문정보
- Research article
- 2021년 05월 (BRIC 등록일 2021-05-12)
- 국내+국외 연구진
- 의약학 > 응용의학
- 120회 이상 인용된 논문 (상위피인용논문 등록일 2024-12-19)
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