한빛사논문
- 조회616
Hanjun Hwangbo,1 Hyeongjin Lee,1 Eun Ji Roh,2 WonJin Kim,1 Hari Prasad Joshi,2 Su Yeon Kwon,2 Un Yong Choi,2 In-Bo Han,2,a) and Geun Hyung Kim1,3,a)
1Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419, South Korea
2Department of Neurosurgery, CHA University School of Medicine, CHA Bundang Medical Center, Seongnam-si, South Korea
3Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, South Korea
H.H., H.L., and E.J.R. contributed equally.
a)Authors to whom correspondence should be addressed.
Abstract
The fabrication of biomimetic scaffolding is a challenging issue in tissue engineering. Scaffolds must be designed with micrometer precision to enable cell proliferation and tissue growth, requiring customization based on the type of tissue being developed. Biomimetic scaffolds have attracted interest for their potential in spinal fusion applications. By providing a structured environment to promote osteogenesis, these materials offer a robust and minimally invasive means to fuse vertebrae. The present study describes the successful preparation of a biomimetic collagen/hydroxyapatite hierarchical scaffold, with each strut having several microchannels via 3D printing, leaching, and coating processes (i.e., one-way shape morphing, 4D printing). The biophysical properties of the scaffold were analyzed, as were its various cellular activities, using human adipose stem cells. This biomimetic microchannel scaffold demonstrated great potential for osteogenic activities in vitro and significantly increased new bone formation and ingrowth of blood vessels in vivo in a mouse model of posterolateral lumbar spinal fusion. These in vitro and in vivo results suggest that the microchannel collagen/hydroxyapatite scaffold could act as a potential bone graft substitute to promote high rates of successful fusion.
논문정보
- Research article
- 2021년 05월 (BRIC 등록일 2021-05-07)
- 국내 연구진
- 바이오·의료융합 > 의료기기
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
관련분야 논문보기
