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Signal Transduct. Target. Ther., Published 9 April 2021, 6, 146 | https://doi.org/10.1038/s41392-021-00589-1 [Research Highlight]Landscapes of SARS-CoV-2-reactive CD8+ T cells: heterogeneity of host immune responses against SARS-CoV-2

June-Young Koh¹ and Eui-Cheol Shin^1,2

¹Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea and ²The Center for Epidemic Preparedness, KAIST, Daejeon, Republic of Korea

Correspondence: Eui-Cheol Shin

Abstract

In a recent study published in Science Immunology,¹ Kusnadi et al. performed single-cell RNA sequencing (scRNA-seq) of SARS-CoV-2-reactive CD8⁺ T cells and reported heterogeneity.

SARS-CoV-2 infection causes COVID-19, which is an ongoing pandemic disease threatening public health. The virology of SARS-CoV-2 and immune responses against the virus have been urgently investigated to develop effective measures against COVID-19. During viral infection, CD8⁺ T cells contribute to elimination of the virus by exerting cytotoxicity against virus-infected cells and producing effector cytokines, whereas neutralizing antibodies interfere with viral entry of host cells.

논문정보

형식Research Highlight
게재일2021년 04월 (BRIC 등록일 2021-04-22)
연구진국내 연구진
분야 의약학 > 면역의학

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