한빛사논문
- 조회616
Rachel E. Younga, Dan Dongeun Huha,b,c,*
aDepartment of Bioengineering, University of Pennsylvania, 210 S 33rd St., Philadelphia, PA, 19104, USA
bInstitute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
cNSF Science and Technology Center for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA 19104
*Corresponding author
Abstract
Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a disruptive in vitro technology for biopharmaceutical applications. By enabling new capabilities to engineer physiological living tissues and organ units in the precisely controlled environment of microfabricated devices, these systems offer great promise to advance the frontiers of basic and translational research in biomedical sciences. Here, we review an emerging body of interdisciplinary work directed towards harnessing the power of organ-on-a-chip technology for reproductive biology and medicine. The focus of this topical review is to provide an overview of recent progress in the development of microengineered female reproductive organ models with relevance to drug delivery and discovery. We introduce the engineering design of these advanced in vitro systems and examine their applications in the study of pregnancy, infertility, and reproductive diseases. We also present two case studies that use organ-on-a-chip design principles to model placental drug transport and hormonally regulated crosstalk between multiple female reproductive organs. Finally, we discuss challenges and opportunities for the advancement of reproductive organ-on-a-chip technology.
Keywords : Organ-on-a-chip, Microphysiological systems, Microfluidics, Reproductive system, Reproductive biology and medicinePregnancy, IVF, Preterm birth
논문정보
- Review Paper
- 2021년 04월 (BRIC 등록일 2021-04-13)
- 국외 연구진
- 바이오·의료융합 > 의료기기
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