한빛사논문
- 조회725
Joonyoung Kang1,2,5, Hyeji Kim3,5, Seong Hwan Hwang4, Minjun Han3, Sue-Hyun Lee1,2,* & Hyoung F. Kim4,*
1Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
2Program of Brain and Cognitive Engineering, College of Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
4School of Biological Sciences, Seoul National University (SNU), Seoul 08826, Republic of Korea.
5These authors contributed equally: Joonyoung Kang, Hyeji Kim.
*Corresponding author
Abstract
The ventral striatum (VS) is considered a key region that flexibly updates recent changes in reward values for habit learning. However, this update process may not serve to maintain learned habitual behaviors, which are insensitive to value changes. Here, using fMRI in humans and single-unit electrophysiology in macaque monkeys we report another role of the primate VS: that the value memory subserving habitual seeking is stably maintained in the VS. Days after object-value associative learning, human and monkey VS continue to show increased responses to previously rewarded objects, even when no immediate reward outcomes are expected. The similarity of neural response patterns to each rewarded object increases after learning among participants who display habitual seeking. Our data show that long-term memory of high-valued objects is retained as a single representation in the VS and may be utilized to evaluate visual stimuli automatically to guide habitual behavior.
논문정보
- Research article
- 2021년 04월 (BRIC 등록일 2021-04-19)
- 국내 연구진
- 바이오·의료융합 > 뇌인지과학
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