구.농수식품
- 조회263
전북대학교 수의과대학
Bai Wei 1, Se-Yeoun Cha 1, Ke Shang 1, Jun-Feng Zhang 1, Hyung-Kwan Jang 2 *, Min Kang 2 *
1Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine and Center for Poultry Diseases Control, Jeonbuk National University, Iksan, South Korea.
2Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine and Center for Poultry Diseases Control, Jeonbuk National University, Iksan, South Korea; Bio Disease Control(BIOD) Co., Ltd., Iksan, South Korea.
* Correspondence
Abstract
Extended-spectrum cephalosporin (ESC) resistance investigated in Salmonella and E. coli from the same chicken was to improve the understanding of the inter-species transmission of ESC resistance determinants in Salmonella and E. coli from a single chicken individual. Fifteen (13.6%) farms and 44 (8.0%) chicken individuals were positive for ESC-resistant E. coli and/or Salmonella, 8 farms (7.3%) and 12 (2.2%) individuals were simultaneously positive for ESC-resistant E. coli and Salmonella. The genetic diversity of ESC resistance determinants in E. coli and Salmonella was observed. Most E. coli isolates (67.6%) produced CTX-M-type of blaCTX-M-55, and 9 isolates (24.3%) produced CMY-type of blaCMY-2. Most Salmonella isolates (94.1%) produced blaCTX-M-15. Two broiler chicken farms were simultaneously positive for blaCMY-2- and blaCTX-M-15-harboring E. coli and Salmonella isolates. Whole-plasmid sequence for the transferable plasmid harboring blaCMY-2 showed genomic diversity of the plasmids from Salmonella and E. coli sourced from the same chicken. The genetic arrangement of blaCMY-2 in Salmonella was IS1294b-ΔISEcp1-blaCMY-2-blc-sugE and ISEcp1-blaCMY-2-blc-sugE in E. coli located on multi-host plasmids of IncI1-pST-2 and IncI1-pST-12. In conclusion, the study illustrates the genetic diversity of ESC resistance determinants in E. coli and Salmonella in a single chicken. Considering the possibility of transmission of antimicrobial resistance to humans through the food chain, a large reservoir of ESC resistance in chicken which could be co-infected with ESC-resistant E. coli and Salmonella poses a serious risk of potential transmission of ESC-resistant E. coli and Salmonella, and their transferable ESC resistant gene, to human simultaneously.
논문정보
- Research article
- 2021년 03월 (BRIC 등록일 2021-03-31)
- 국내 연구진
- 구・농수식품
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