한빛사논문
- 조회1,043
Il-Geun Parka, Minsol Jeonb,c, Hyunkyung Kimb,c,*, Ji Min Leea,*
aDepartment of Molecular Bioscience, College of Biomedical Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea
bDepartment of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 02841, Republic of Korea
cDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea
*Corresponding author.
Abstract
Methylation is a major post-translational modification (PTM) generated by methyltransferase on target proteins; it is recognized by the epigenetic reader to expand the functional diversity of proteins. Methylation can occur on specific lysine or arginine residues localized within regulatory domains in both histone and nonhistone proteins, thereby allowing distinguished properties of the targeted protein. Methylated residues are recognized by chromodomain, malignant brain tumor (MBT), Tudor, plant homeodomain (PHD), PWWP, WD-40, ADD, and ankyrin repeats by an induced-fit mechanism. Methylation-dependent activities regulate distinct aspects of target protein function and are largely reliant on methyl readers of histone and nonhistone proteins in various diseases. Methylation of nonhistone proteins that are recognized by methyl readers facilitates the degradation of unwanted proteins, as well as the stabilization of necessary proteins. Unlike nonhistone substrates, which are mainly monomethylated by methyltransferase, histones are di- or trimethylated by the same methyltransferases and then connected to other critical regulators by methyl readers. These fine-tuned controls by methyl readers are significant for the progression or inhibition of diseases, including cancers. Here, current knowledge and our perspectives about regulating protein function by methyl readers are summarized. We also propose that expanded research on the strong crosstalk mechanisms between methylation and other PTMs via methyl readers would augment therapeutic research in cancer.
Keywords : Chromodomain, Tudor, PHD, Epigenetics, Methyl reader
논문정보
- Review Paper
- 2021년 03월 (BRIC 등록일 2021-03-24)
- 국내 연구진
- 의약학 > 분자세포의학
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